Missed Base/Appeal

[buckyswider]

I guess a scenario with larger ramifications would be a time play on the 3rd out (other than at first base, obviously). R1, two outs. Batter hits a gapper. B1 touches first, misses second. B1 almost to third. F4 receives the throw, steps on second requesting appeal before R1 touches home plate.

I'd grant the appeal and wipe out the run. Not sure I'm right, though.