Runner from First to Second

[JFA67]

I think so. Especially if the second baseman sets up closer to first than normal. For example cheating over to cover first on a sac bunt.
As long as you aren't so far that you can't get an angle on a pickoff throw from the catcher.

[CLBuffalo]

As I approach 62 the bases get father apart and the runners get faster. I set up about 2/3 of the way to second. If the 2nd base person is in front of me I take a step or 2 to the left towards 1st base. In your pregame with your partner make sure they will be watching the pick off attempt and are ready to help with a close call or you possibly being blocked on the play. I've worked with PUs who WANT to make the pick off call at 1st.

[CecilOne]

I always stay as close to 1st as the fielders let me, minimum of 15-20feet. Pickoff plays happen much faster and are harder to call from a poor angle than the steal at 2nd. But I also adjust for the game situation, the catcher's tendency to throw and the runner's speed.