NCAA team vs. Fed team

[Texas Aggie]

Since I'm unfamiliar with Fed rules, I'd like to inquire from those familiar with both: what happens, playing and strategy wise (if anything) in a game matching up a team used to NCAA rules vs. a team used to Fed rules? Is one team going to need to change some things they do? I realize it may depend on many things, but mention various offenses/defenses, special teams, etc.