Does the run score?

[UmpTTS43]

When you have F2 attempt a play when the now retired batter interferes, you kill it immediately "Time, that's interference. Batter, you're out on strikes" point to runner F2 wanted to play on, "Runner you're out for the interference" Then send other runners back.

On a side note, the initial throw interpretation only applies to OBR. In NCAA, and FED I believe, as soon as F2 makes an attempt and aborts his throw, the play is dead regardless if F2 subsequently throws to another base and retires a runner.

In all reality, F2 will know if R3 is running on the pitch. The most common senario is a delayed steal, R1 runs to draw a throw, R3 breaks on the throw or a suicide squueze.