Pickoff away from Base

[LilLeaguer]

OBR

8.05 (c) and (d) both refer to throws by the pitcher to a base, but J/R (Ch. 18, 11(d)) say that you can step to 2nd, say, and throw to a player away from the base.

At the level of play I'm seeing right now, R2 might be leading off 'way too far, say 1/3 of the way to 3B.

Is it a balk for a pitcher to step to F6 and throw the ball, if the runner is actually in the vicinity of F6 (and away from 2B)? I haven't seen it yet, but it could happen. Would it be OK (per J/R) if the step were towards 2B? From position C, I think I'd be able to tell the difference.

Perhaps the precedent is with lefties picking off at 1st. The step is considered to be either towards 1B or HP, based on the 45-degree angle. Is every step by a pitcher judged to be towards one base or another?

Thanks,
-LilLeaguer