I wouldn't. Not to that comment, at least. He wants you to say something so he can go off on you. Just say, "OK", and move on. Chances are he won't say another word and will get pissed (mostly at himself) because you weren't baited into a fight.
Guys, take my word for it, the letters O followed by K does wonders. You obviously have other tools at your disposal, but if it isn't a question, why respond?