Rule on this one.

[blu_bawls]

There is no force out at first nullifying the runs. Any baserunner who crossed the plate before the appeal or the out/ejection would score and the the run would stay on the books.

Once a runner has crossed a base he is assumed to have touched that base until an appeal is made.

2 outs with R1 on 3rd, B2 hits a fast grounder to right field. B2 crosses the base (but does not touch the orange part of the bag) before the throw from right field reaches F3 you MUST call B2 safe. During this time R1 scores.

As B2 walks back to first base, she is tagged by the first baseman who appeals she didn't touch the base. Run scores and the inning counts.