Missing base after bases loaded home run

[Hearls3]

What is the ruling should a homerun be hit with men on base. Say our team is down by 2, 2 outs and BR on 1st and 2nd. Homerun is hit over the fence and runner misses first base, do any runs score?, how many?

Is there a big league story when this happened and a team went from thinking they have just won the game to loosing the game because the runner is called out?

Thanks for your help.....