In FED the DH and the player DHed for are locked into the same spot. This assumes in the original question that the pitcher is the started being DHed for.
In OBR -- on defense the team can make multiple changes and choose where the players will go in the lineup.
On offense, the game pitcher can only pinch-hit for the DH. Now, I would extend that to mean pinch-run as well even though it is not specifically listed in the OBR.
Rich
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