The most common way, and really only way barring anything bizzare, you get an obstruction on F1 is when we have a dribbler up the line and F3 moves into field. F1 peels off to allow F3 to field, and causes a change in stride in the B/R.
In this situation, as others have said, F1 should be protected as long as he doesn't bobble beyond a step and a reach.
Also, it should be noted that the 45 foot runner's lane has nothing to do with this call.
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