Yes, if you judge it to be intentional.
I'm assuming that there was a change of possession during the play prior to the holding foul. A is the team that puts the ball into play and B is the opponent. The offense is the team in possession of the ball and the defense is the opponent. Just checking...
My working definition of holding is any intentional act not permited by rule that prevents an opponent from moving. Based on your example, I would not have a holding foul unless it was near the point of attack. In my view what you would have in most cases is a legal "pancake" block. So I would caution you to get a good look at the action and rule a legal block if you are not sure.
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Mike Simonds
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