I don't think either factor in the last sentence (Since R2 was nearly back to 2nd and couldn't have been picked, and neither runner advanced on play, how was defense harmed?) matter as to whether the batter interfered with the play. Whether there was a possibility of play usually affects the call. But, you have to assume that the catcher might have thrown to 2nd and that R2 might fall down, or the throw to either base is missed causing R2 to try for 3rd, etc., etc. That would make the call interference.
However, it's the batter that would be out, not the runner and both runners stay where they were.
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