At lower levels up to high school the fans, as long as they do not get personal and way out of line the response is none.
If they get way out of line then they could get to see the outside of the building and what ever punnishment the local administrators deem necessary.
This would include some high school venues also but in most cases at this level and above you tune them out and /or tell jokes about them at halftime.
did you hear the one about the fan that ...
Two fans walked into a bar ...
It comes with the territory and you have little control over them. If you get directly involved with them they win. It is best to let others handle it if possible.