There is no restriction on ineligibles going downfield IF the pass does not cross the line of scrimmage. On a properly executed middle screen, it won't.
But I'd guess your question is prompted by a situation that occured in one of your games. My guess is that a middle screen was attempted but the receiver missed the ball, or it was overthrown, and the pass crossed the neutral zone while the blockers were downfield. That would be a foul for ineligibles downfield, or maybe even offensive pass interference.
So the simple answer to your question is - two yards, the width of the expanded neutral zone.
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