No, the ball does not have to hit the runner in order for it to be interference, If in the umpires judgement the runner being out of the running lane caused a bad throw,ie.over her head and the fielders head or wide, while throwing around her, she is out. However the fielder must make an attempt. As for one foot in and one foot out, every other step the runner is in the lane since only one foot is on the ground at a time.
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