Try these examples:
Fielder, while attempting to take throw, sticks out his leg and slightly trips runner going to second. Obstruction?
Runner on his way to second, tries an Arod play and attempts to slap the ball or glove of the fielder, to prevent a play from being made. Interference?
Everything in between, including malicious contact will be your judgement. As already suggested here, your best call, may not be any call at all.
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