Depends on which rules you're talking about.
Under LL rules (where I coach and officiate), once a pitcher is removed from the mound, he can't pitch again. Under ORB, if the pitcher remains on the field (moves to another position) he come back and pitch again.
In either rule system, a pitcher can leave the mound, but stay in the game in a different position.
In LL, a pitcher can leave the game and re-enter in a different position in a later inning. In ORB, once a player leaves the game, he can't come back.
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