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Last year I had a game with only 5 players dressed and my assistant asked if we could pull a player and go with 4 if we needed to rest somebody. I looked at him like he was crazy and the ref politely informed him that we needed to keep 5 players on the floor. I explained later to him that we could run a delay game if the players got tired. In an extreme case, I could pull a player back to only defense if I needed to to keep him rested. Never did the latter but did a lot of the former - got the W, despite losing our center with 4 minutes to play and while holding a 5 point lead. Perhaps my asst was on to something though - we ended up outscoring them while down a man!
As for injuries, it's no different than a guy coming out and returning when there are 10 players on the bench. Coach's decision as to when player is able to return to action, unless you see a concussion, safety problem or blood.
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