Penalty following change of possession

[PiggSkin]

KWH: Is there a case book play or something that you can point me to..?

The last sentence of the previously mentioned 5-3-1 is this:
The line to gain then remains fixed until the series ends and a new line to gain is established.

Following that, I don't see how we can "un-establish" the LTG, simply because a timeout was called...

Can you elaborate..?